made in france gluten free lactose free ogm free vega

Magnesium + Potassium + B6

Magnesium + Potassium and Vitamin B6 : An ideal formula to increase muscle tone and reduce nervous fatigue and better regulate cellular water retention – 60 capsules

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Made in france ES
Sans gluten UK
sans lactose UK
sans ogm UK
vegan ES

60 capsules rich in Magnesium and Potassium: essential minerals for improving muscle tone, nervous balance and cellular water retention.

A significant dosage :

For two capsules: 80% of the adult RDI in Magnesium, 10% of the RDI in Potassium (without risk of overdosing even with other dietary intakes) and 100% of the RDI in vitamin B6.

Synergy of assets : 

In addition to the classic effects of magnesium (tonicity, anti-fatigue, etc.), the addition of potassium helps to counterbalance the effects of sodium (table salt) to better regulate cellular water retention.

Other advantages and qualities :

  • Certified Vegan by The vegetarian Society
  • Eco-responsible packaging, product made in France
  • Synergy with the Calcium + Vitamin D3 and Boron supplement to strengthen the bone capital
  • Capsule Only with natural additive (rice bran)
  • No dyes or allergens

The benefits of magnesium :

The benefits of Magnesium are numerous.
It helps the muscles to function properly and reduce the feeling of fatigue. Magnesium supports the body’s regeneration processes and improves the quality of sleep.

It also contributes :

  • To the functioning of the nervous system
  • Energy metabolism
  • Maintenance of bones and teeth
  • Protein synthesis
  • To muscle contraction
  • To the electrolytic balance which determines the cell water retention
  • To reduce fatigue

The benefits of vitamin B6 :

Vitamin B6 promotes the entry of magnesium into the capsule.
It is not synthesised by the body, yet it is essential because it acts as a cofactor for numerous enzymes. (vitamin B6 catalyses certain biochemical reactions).
It is involved in the metabolism of amino acids and also in that of neurotransmitters.
Therefore, it contributes directly to :

  • To the functioning of the nervous system and the immune system
  • To normal psychological functions,
  • To the reduction of fatigue and exhaustion,
  • To the regulation of hormonal activity.

The benefits of Potassium :

Daily Potassium requirements have been re-evaluated in 2016 by more than 40% (adult: 3500 mg daily – ANSES) for its importance in cardiac regulation, the nervous and muscular system, ossification, glycaemia regulation and to counterbalance the effects of Sodium on cellular water retention. 

Complementary Magnesium and Potassium supplements:

Additional Potassium and Magnesium supplements during a long course of treatment improve the regulation of cellular water retention and the reduction of related discomforts (swollen legs, etc.) (Walker et al. study).

A complete deficiency of these two minerals is impossible because they are present in all foods, but insufficient intakes are frequent: supplementation makes it possible to reach an optimal level easily.

These deficits (or more exactly these sub-optimal intakes, especially for Magnesium: SUVImax and INRA studies) are quite frequent in the French population: the Argalys formula makes it possible to secure these intakes, for all diets and particularly: sportsmen and women, pregnant and breastfeeding women, senior citizens or for consumers during slimming diets.

When to take Argalys Magnesium/Potassium? 

Only one capsule per dose, during or after meals (it is important for better assimilation to take the capsule when gastric acidity is at its maximum).

How many capsules?

* Adults : Up to 2 capsules per day.
Period of stress: 2 capsules per day.

* From 8 to 16 years: 1 capsule per day.

How to take your capsules? 

To be taken with a glass of water.

For whom? 

For everyone from 8 years old.

Precautions for use :

Food supplement based on magnesium and potassium, to be used as a complement to a healthy and balanced diet.

Do not exceed the recommended daily doses.

Pregnant and breastfeeding women should seek medical advice before taking any supplements.

Storage conditions :

Store in a dry place away from light and heat. Keep out of reach of children.

2 Argalys Magnesium Potassium capsules contains :
  • 300 mg of Magnesium or 80% of the adult NRV
  • 200 mg of Potassium, i.e. 10% of the NRV
  • 1.4 mg of vitamin B6 or 100% of the NRV
Ingredients : Potassium bicarbonate, magnesium bisglycinate, marine magnesium oxide, pyridoxine hydrochloride (B6). Additive: rice bran. HMPC vegetal capsule.

The benefits of Argalys Magnesium + Potassium

Poor dietary balance, physical exertion, stress or significant water loss (sweating, diarrhoea, etc.) can lead to a magnesium or potassium deficiency.

In the diet, sodium intake (e.g. table salt) is important and often difficult to control (‘hidden’ salt in prepared foods) and excess sodium has a direct effect on water retention.
Potassium counteracts this effect.

The formula is designed to restore the acid-base balance, essential for the proper functioning of the body.

Moreover, magnesium is a mineral essential to the body’s physiological balance and is indispensable for more than 300 enzymatic reactions.

The importance of Potassium

Potassium is essential to the body.

It is an electrolyte: its electrical affinity is essential for the biochemical reactions of the body, particularly for the circulation of nerve impulses, the balance of the internal pH and the cell absorption mechanisms (hence its influence on water retention).

The choice of Magnesium

Magnesium is the fourth most common mineral in the body.

Especially known for its action on reducing stress and fatigue, it contributes to more than 300 cellular biochemical reactions.

It is involved in the proper functioning of the muscular and nervous systems, energy production, bone health, protein and DNA synthesis etc.

Food is the only source of Magnesium.

Lack of magnesium in the diet

The SU.VI.MAX nutritional survey revealed that 75% of French people have intakes below the ANC (Recommended Nutritional Intakes), which can be explained by :

  • Foods that are low in micronutrients (ready meals, )
  • Insufficient consumption of fruit, vegetables and dry seeds

Finally, stress and physical exertion increase magnesium expenditure and require corrective measures.
The ANC of magnesium is 6 mg per day and per kilo: (see table below)


Source : Dietary Reference Intakes for Calcium, Phosphorous, Magnesium, Vitamin D, and Fluoride, 1997, Institute of Medicine, Food and Nutrition Board.

Why we chose magnesium oxide :

Magnesium oxide is a good source of magnesium.

Its high Magnesium content more than compensates for its lower solubility compared to other magnesium salts. Per gram of salt, it is the form that provides the most absorbed magnesium.

The importance of gastric acid

In all its natural forms, magnesium is bound to another chemical compound: carbonate, gluconate, citrate, lactate, aspartate or oxide. These combinations are called magnesium salts.

None of these salts is directly assimilated by the body: the first step in absorption is always the separation of magnesium from its carrier. 

This operation is carried out by stomach acid, which is why it is preferable to take Magnesium supplements during a meal or immediately afterwards (rather than before the gastric acid secretions have not started) .

Magnesium oxide provides more elemental magnesium

The amount of magnesium actually absorbed into the body depends on the concentration of the salt chosen and the rate of absorption.
The percentage of elemental magnesium is as important as its absorption rate.

Magnesium oxide always provides more magnesium for the same initial concentration.

The meta-study (synthesis study) by Ranade et al (2001) gives the following values (content and absorption) for the different magnesium salts present in commerce.

Comparison of magnesium salts – meta study Ranade et al (2001)
Magnesium salts Magnesium content % Average absorption rate Magnesium absorbed per gram of salt
Oxide 60% 23% 13.8
Carbonate 28% 20% 5.2
Chloride 26% 20% 5.2
L-lactate 12% 42% 5.0
Citrate 11% 30% 3.3
Aspartate 8% 42% 3.3
Glycinate 14% 23% 3.2
Gluconate 6% 19%

1.1

Magnesium oxide is the form that provides the most elemental magnesium per gram of salt ingested.

Magnesium oxide: a false polemic?

On the web, many sites claim that only 4% of the magnesium in magnesium oxide is absorbed.
This claim is based on a small study by Firoz et al (2001), which is discussed in detail below. The conclusions of this study show a very different reality.

The purpose and method of the study Firoz et al (2001) :

The aim of this study was to measure the difference in absorption between organic (chelated) magnesium salts (e.g. aspartate, lactate) and inorganic salts (oxide, chloride).

The methodology was based on the measurement of urinary magnesium* in a small group of test patients (16), each receiving daily magnesium supplementation with 4 different salts (oxide, chloride, aspartate, lactate) + 2 days of control without intake.

*Considering that if Magnesium was present in urine, it is because it had been previously absorbed: this simplification is nevertheless very approximate (see § below Immediate bioavailability Vs real effectiveness) 

The results of the study Firoz et al (2001) :

Measurement of urinary magnesium, mg/litre
Candidate MG

oxide

MG

chloride

MG

aspartate

MG

lactate

Control 1* 2* control
A 100 156 95 114 77 70
B 95 43 78 65 68 43
C 101 89 103 137 75 32
D 66 120 137 161 100 103
E 78 166 101 119 134 65
F 63 144 88 48 56 67
G 84 78 76 67 74 61
H 142 182 214 198 128 129
I 78 39 55 62 102 60
J 114 112 110 76 53 86
K 77 106 177 116 80 32
L 114 94 137 117 109 92
M 66 87 51 81 104 115
N 82 82 82 163 76 85
O 162 133 85 106 75 75
p 34 120 58 87 28 57

 

Analysis of results (Bold underlined: the lowest scores for each individual)

Lowest absorption scores of the 16 individuals tested :

  • 6 for magnesium oxide
  • 4 for chloride mg
  • 4 for aspartate
  • 5 for lactate

Conclusion 1: The differences between individuals are significant and the absorption of different salts varies greatly from one person to another. The nature of the salt therefore does not give an absolute guarantee of better absorption.

Conclusion 2: Comparison with control days without supplementation shows a positive effect of supplementation in all cases and with all forms of salts.

Magnesium oxide is actually properly absorbed.

Other studies have confirmed these two general trends:

  • In 1994, several American scientists (Altura BT, Wilimzig C, Trnovec Tetc. ) studied the effects of a diet enriched with Mg and different magnesium oxide preparations (4).
  • In 2005: a study was published in Magnesium Research, the official journal of the International Society for the Development of Magnesium Research (SDRM) (5)
  • In 2014, 4 researchers (Jesse Bertinato, Louise J. Plouffe, Christopher Lavergne and Catherine Ly) studied the bioavailability of magnesium between inorganic and organic compounds (6).

The conclusions of these studies are as follows:

  • The absorption of Magnesium Salts is very variable in all cases;
  • But all complementary inputs are

Immediate bioavailability of magnesium vs. real efficiency

High bioavailability means a rapid rate of absorption into the bloodstream.

This results in a significant increase in blood magnesium, and in the most frequent cases, in rapid urinary elimination as soon as the saturation threshold is reached (see the Firoz study which measures the level of urinary magnesium as a marker of absorption).

The magnesium from oxide is absorbed more slowly.

This results in a lower blood peak and consequently less urinary excretion: a better efficiency for the organism (this relationship is totally consistent with the results of the Firoz et al. (2001) study cited above).

Our conclusions for the Magnesium + Potassium Formula: effectiveness first and foremost

The concentrated form of Magnesium used allows significant intakes of Magnesium (100% RDI) and Potassium (15%) with 2 capsules per day.

This would not have been possible with the other less concentrated magnesium salts: we wanted to combine these two minerals to add to the usual effects of magnesium the action on cellular water retention.

Taking a meal during or at the end of the meal allows the action of the gastric acid which is an important factor for the good absorption of magnesium.

Bibliography :

Magnesium and stress :

  • https://journals.eco-vector.com/0040-3660/article/view/31844
  • https://www.ncbi.nlm.nih.gov/books/NBK507250/
  • http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.1032.5604&rep=rep1&type= pdf

Magnesium and water retention :

  • (Pre-Menstrual Syndrome) https://pubmed.ncbi.nlm.nih.gov/9861593/
  • Walker AF et al. Magnesium supplementation alleviates premenstrual symptoms of fluid J Womens Health 1998 Nov 7 11571165

Potassium and water retention :

  • https://www.health.harvard.edu/staying- healthy/potassium_and_sodium_out_of_balance
  • https://pubmed.ncbi.nlm.nih.gov/9428447/
  • Updating the PNNS benchmarks: revision of food consumption benchmarks.

November 2016.

  1. Kieneker & al. Urinary potassium excretion and risk of developing
  • hypertension: the prevention of renal and vascular end-stage disease

Hypertension. 2014 ; 64 : 769–776.

  • Dickinson & al. Potassium supplementation for the management of primary hypertension in adults. Cochrane Database of Systematic Reviews. 2006 ; 3 : CD004641.
  • A. New & al. Dietary influences on bone mass and bone metabolism: further evidence of a positive link between fruit and vegetable consumption and bone health? American Journal of Clinical Nutrition. 2000; 71 : 142–151.

Absorption of magnesium oxide and other forms of magnesium oxide :

  • Ranade et al (2001): Download the study: here
  • Firoz M, Graber M. Bioavailability of US commercial magnesium: https://www.researchgate.net/publication/11563416_Bioavallability_of_US_commercial_ magnesium_preparations
  • (4) Altura BT, Wilimzig C, Trnovec T, et al. Comparative effects of a Mg-enriched diet and different orally administered magnesium oxide preparations on ionized… https://www.tandfonline.com/doi/abs/10.1080/07315724.1994.10718433?journalCodeuacn20
  • (5) Coudray C, Rambeau M, Feillet-Coudray C, et al. Study of magnesium bioavailability from ten organic and inorganic Mg salts in Mg-depleted… https://pubmed.ncbi.nlm.nih.gov/16548135/
  • (6) Bertinato J, Plouffe LJ, Lavergne C, et al. Bioavailability of magnesium from inorganic and organic compounds is similar in rats fed a high phytic acid diet… https://pubmed.ncbi.nlm.nih.gov/25635418/
  • Molecular weights: https://pubchem.ncbi.nlm.nih.gov/compound/magnesium_oxide For the other magnesium salts, replace oxide with the name of salt
FAQ - WE ANSWER YOUR QUESTIONS
How do I know if I need magnesium?
It is always a delicate question! Symptoms: fatigue, cramps and tingling, increased sensitivity to stress, high blood pressure and even dizziness are warning signs of a possible lack of magnesium... This is quite common because daily requirements are high (300 to 400 mg for adults). Low consumption of nuts or vegetables, or cooking with water, or ultra-processed foods are risk factors for magnesium deficiency. And yes, chocolate can't make up for everything!
How long does the magnesium cure last?
The 60 capsules of our Magnesium supplement allow for a two-month treatment as a maintenance diet (one capsule/day). However, the dosage allows for a long-term intake if the basic diet remains deficient. It is also possible to take 2 capsules/day for a booster effect for about ten days (100% of the RDI with 2 capsules).
Why did you combine magnesium with potassium?
Potassium needs are very important (3500 mg/day) for cardiac regulation, the nervous and muscular system, ossification, regulation of glycemia and to counterbalance the effects of Sodium on cellular water retention. It therefore seemed useful to us to add a 'plus' of Potassium to optimize all these functions. The combination of the two is very innovative, and even more so with the addition of vitamin B6!
What is the purpose of the vitamin B6 in your supplement?
Vitamin B6 completes the anti-fatigue, anti-stress action of magnesium. From the point of view of perceptible effectiveness on these two targets, the association of magnesium and vitamin B6 is very relevant.
Can your Magnesium, Potassium and Vitamin B6 formula cause intestinal problems?
In the vast majority of cases: no! It is formulated to minimize this risk with a reasonable dosage of Magnesium and contributions divided between two different salts (marine oxide and Bisglycinate).

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